Recent publications:

 
Multidimensional analysis of Gammaherpesvirus RNA expression reveals unexpected heterogeneity of gene expression

Multidimensional analysis of Gammaherpesvirus RNA expression reveals unexpected heterogeneity of gene expression

Tumor-Intrinsic Response to IFNy Shapes the Tumor Microenvironment and Anti-PD-1 Response in NSCLC

Tumor-Intrinsic Response to IFNy Shapes the Tumor Microenvironment and Anti-PD-1 Response in NSCLC

High-Dimensional Characterization of IL-10 Production and IL-10–Dependent Regulation during Primary Gammaherpesvirus Infection

High-Dimensional Characterization of IL-10 Production and IL-10–Dependent Regulation during Primary Gammaherpesvirus Infection

Targeting DDR2 enhances tumor response to anti–PD-1 immunotherapy

Targeting DDR2 enhances tumor response to anti–PD-1 immunotherapy

A Beginner’s Guide to Analyzing and Visualizing Mass Cytometry Data

A Beginner’s Guide to Analyzing and Visualizing Mass Cytometry Data

Selected Publications

  1. Kimball, A.K., Oko, L.M., Kaspar, R.E., van Dyk, L. F., & Clambey, E. T. (2019) High-dimensional analysis of IL-10 Producing Cells and the Impact of IL-10 on Anti-Viral Responses. Immunohorizons, 3(3), 94-109.

  2. Tu, M. M., Lee, F. Y., Jones, R. T., Kimball, A. K., Saravia, E., Graziano, R. F., ... & Chang, H. (2019). Targeting DDR2 enhances tumor response to anti–PD-1 immunotherapy. Science Advances, 5(2), eaav2437.

  3. Mahalingam R, Kaufer BB, Ouwendijk WJD, Verjans GMGM, Coleman C, Hunter M, Das A, Palmer BE, Clambey E, Nagel MA, Traina-Dorge V. Attenuation of Simian Varicella Virus Infection by Enhanced Green Fluorescent Protein in Rhesus Macaques. J Virol. 2018 Jan 17. PMID: 29343566.

  4. Niemeyer BF, Oko LM, Medina EM, Oldenburg DG, White DW, Cool CD, Clambey ET, van Dyk LF. Host Tumor Suppressor p18INK4c functions as a potent cell-intrinsic inhibitor of gHV68 reactivation and pathogenesis. J Virol. 2018 Jan 03. PMID: 29298882.

  5. Kimball AK, Oko LM, Bullock BL, Nemenoff RA, van Dyk LF, Clambey ET. A Beginner’s Guide to Analyzing and Visualizing Mass Cytometry Data. J Immunol. 2018 Jan 01; 200(1):3-22. PMID: 29255085.

  6. Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris JD, Clambey ET, Thurman JM, Nemenoff RA. Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018 Jan 01; 78(1):143-156. PMID: 29118090.

  7. Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20; 9(408). PMID: 28931657.

  8. Li HY, McSharry M, Bullock B, Nguyen TT, Kwak J, Poczobutt JM, Sippel TR, Heasley LE, Weiser-Evans MC, Clambey ET, Nemenoff RA. The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade. Cancer Immunol Res. 2017 Sep; 5(9):767-777. PMID: 28819064.

  9. Oweida A, Lennon S, Calame D, Korpela S, Bhatia S, Sharma J, Graham C, Binder D, Serkova N, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD. Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma. Oncoimmunology. 2017; 6(10):e1356153. PMID: 29123967.

  10. Nelsen MK, Beard KS, Plenter RJ, Kedl RM, Clambey ET, Gill RG. Disruption of Transplant Tolerance by an “Incognito” Form of CD8 T Cell-Dependent Memory. Am J Transplant. 2017 Jul; 17(7):1742-1753. PMID: 28066981.

  11. Eberlein J, Davenport B, Nguyen T, Victorino F, Haist K, Jhun K, Karimpour-Fard A, Hunter L, Kedl R, Clambey ET, Homann D. Aging promotes acquisition of naive-like CD8+ memory T cell traits and enhanced functionalities. J Clin Invest. 2016 Oct 03; 126(10):3942-3960. PMID: 27617858.

  12. Cicchini L, Westrich JA, Xu T, Vermeer DW, Berger JN, Clambey ET, Lee D, Song JI, Lambert PF, Greer RO, Lee JH, Pyeon D. Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14. MBio. 2016 05 03; 7(3). PMID: 27143385; PMCID: PMC4959654.

  13. Henry CJ, Casás-Selves M, Kim J, Zaberezhnyy V, Aghili L, Daniel AE, Jimenez L, Azam T, McNamee EN, Clambey ET, Klawitter J, Serkova NJ, Tan AC, Dinarello CA, DeGregori J. Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. J Clin Invest. 2015 Dec; 125(12):4666-80. PMID: 26551682; PMCID: PMC4665776.

  14. Victorino F, Sojka DK, Brodsky KS, McNamee EN, Masterson JC, Homann D, Yokoyama WM, Eltzschig HK, Clambey ET. Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody. J Immunol. 2015 Nov 15; 195(10):4973-85. PMID: 26453755; PMCID: PMC4640895 [Available on 11/15/16].

  15. Williams LM, Niemeyer BF, Franklin DS, Clambey ET, van Dyk LF. A Conserved Gammaherpesvirus Cyclin Specifically Bypasses Host p18(INK4c) To Promote Reactivation from Latency. J Virol. 2015 Nov; 89(21):10821-31. PMID: 26292318; PMCID: PMC4621100.

  16. Diebel KW, Oko LM, Medina EM, Niemeyer BF, Warren CJ, Claypool DJ, Tibbetts SA, Cool CD, Clambey ET, van Dyk LF. Gammaherpesvirus small noncoding RNAs are bifunctional elements that regulate infection and contribute to virulence in vivo. MBio. 2015 Feb 17; 6(1):e01670-14. PMID: 25691585; PMCID: PMC4337559.

  17. Desch AN, Gibbings SL, Clambey ET, Janssen WJ, Slansky JE, Kedl RM, Henson PM, Jakubzick C. Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction. Nat Commun. 2014 Aug 19; 5:4674. PMID: 25135627; PMCID: PMC4153365.

  18. Clambey ET, Davenport B, Kappler JW, Marrack P, Homann D. Molecules in medicine mini review: the aß T cell receptor. J Mol Med (Berl). 2014 Jul; 92(7):735-41. PMID: 24848996; PMCID: PMC4269364.

  19. Bartels K, Karhausen J, Clambey ET, Grenz A, Eltzschig HK. Perioperative organ injury. Anesthesiology. 2013 Dec; 119(6):1474-89. PMID: 24126264; PMCID: PMC3929362.

  20. McNamee EN, Korns Johnson D, Homann D, Clambey ET. Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function. Immunol Res. 2013 Mar; 55(1-3):58-70. PMID: 22961658; PMCID: PMC3919451.

  21. Clambey ET, Collins B, Young MH, Eberlein J, David A, Kappler JW, Marrack P. The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells. PLoS One. 2013; 8(2):e57435. PMID: 23483882; PMCID: PMC3585008.

  22. Ehrentraut H, Clambey ET, McNamee EN, Brodsky KS, Ehrentraut SF, Poth JM, Riegel AK, Westrich JA, Colgan SP, Eltzschig HK. CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury. FASEB J. 2013 Jun; 27(6):2207-19. PMID: 23413361; PMCID: PMC3659359.

  23. Collins B, Clambey ET, Scott-Browne J, White J, Marrack P, Hagman J, Kappler JW. Ikaros promotes rearrangement of TCR a genes in an Ikaros null thymoma cell line. Eur J Immunol. 2013 Feb; 43(2):521-32. PMID: 23172374; PMCID: PMC3923402.

  24. Grenz A, Kim JH, Bauerle JD, Tak E, Eltzschig HK, Clambey ET. Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-a release. J Immunol. 2012 Nov 01; 189(9):4566-73. PMID: 23028059; PMCID: PMC3651815.

  25. Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2784-93. PMID: 22988108; PMCID: PMC3478644.

  26. Grenz A, Clambey E, Eltzschig HK. Hypoxia signaling during intestinal ischemia and inflammation. Curr Opin Crit Care. 2012 Apr; 18(2):178-85. PMID: 22322265; PMCID: PMC3855266.

  27. Ehrentraut H, Westrich JA, Eltzschig HK, Clambey ET. Adora2b adenosine receptor engagement enhances regulatory T cell abundance during endotoxin-induced pulmonary inflammation. PLoS One. 2012; 7(2):e32416. PMID: 22389701; PMCID: PMC3289657.

  28. Kemmler CB, Clambey ET, Kedl RM, Slansky JE. Elevated tumor-associated antigen expression suppresses variant peptide vaccine responses. J Immunol. 2011 Nov 01; 187(9):4431-9. PMID: 21940675; PMCID: PMC3334317.

  29. Koeppen M, Di Virgilio F, Clambey ET, Eltzschig HK. Purinergic regulation of airway inflammation. Subcell Biochem. 2011; 55:159-93. PMID: 21560048.

  30. Clambey ET, Torres RM. Activation or suppression? T cell immunity in COPD lungs. COPD. 2009 Apr; 6(2):84-5. PMID: 19378220.

  31. MacLeod MK, Clambey ET, Kappler JW, Marrack P. CD4 memory T cells: what are they and what can they do? Semin Immunol. 2009 Apr; 21(2):53-61. PMID: 19269850; PMCID: PMC2679806.

  32. Clambey ET, White J, Kappler JW, Marrack P. Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12997-3002. PMID: 18728183; PMCID: PMC2525558.

  33. Jones-Carson J, McCollister BD, Clambey ET, Vázquez-Torres A. Systemic CD8 T-cell memory response to a Salmonella pathogenicity island 2 effector is restricted to Salmonella enterica encountered in the gastrointestinal mucosa. Infect Immun. 2007 Jun; 75(6):2708-16. PMID: 17403871; PMCID: PMC1932863.

  34. Clambey ET, Kappler JW, Marrack P. CD8 T cell clonal expansions & aging: a heterogeneous phenomenon with a common outcome. Exp Gerontol. 2007 May; 42(5):407-11. PMID: 17197145; PMCID: PMC1905459.

  35. Clambey ET, van Dyk LF, Kappler JW, Marrack P. Non-malignant clonal expansions of CD8+ memory T cells in aged individuals. Immunol Rev. 2005 Jun; 205:170-89. PMID: 15882353.

  36. Clambey ET, Virgin HW, Speck SH. Characterization of a spontaneous 9.5-kilobase-deletion mutant of murine gammaherpesvirus 68 reveals tissue-specific genetic requirements for latency. J Virol. 2002 Jul; 76(13):6532-44. PMID: 12050366; PMCID: PMC136253.

  37. Clambey ET, Virgin HW, Speck SH. Disruption of the murine gammaherpesvirus 68 M1 open reading frame leads to enhanced reactivation from latency. J Virol. 2000 Feb; 74(4):1973-84. PMID: 10644370; PMCID: PMC111675.